Sunday, August 24, 2008

Pharmaceutical Analysis




  • Analysis are of two types:- - -



  1. Qualitative Analysis.


  2. Quantitative analysis.



  • Quantitative analysis are also of two types:- - -



  1. Volumetric Analysis.


  2. Titrimetric Analysis.



  • Quantitative chemical analysis carries out by determining the volume of solutions of accurately known as concentration which is required to react quantitatively with a measured volume of the solution of the substance to be determined.


  • Standard Solution: The solution of accurately known strength is known as Standard solution.


  • The reagent of known concentration is called TITRANT and substance being titrized called TITRAND.


  • Process of adding the standard solution until the reaction is just complete is also termed as TITRANT.


  • Process at which chemical or colour change occurs is known as equivalence point and theorotical point and stoichiometric end point.


  • The completion of titrant is detected by some physical change of the standard solution.

In titrimetric analysis reaction must obey the follwing condition : - - -




  • They must be a simple reaction which can be expressed by chemical equation.


  • Reaction should be realtively passed.


  • There must be an alteration in some physical and chemical properties of the solution and equivalence point.


  • An indicator should be available in physical properties should sharply defines the end point of the solution.

Classification of reaction in titrimetric analysis: - - -




  1. Neutralisation reaction and acidimety and alkalimetry.


  2. Complex formation reaction.


  3. Precipitation reaction.


  4. Oxidation and reduction reaction.



  • This includes titration of free bases, those are formed from the salts of weak acid by hydrolysis with a standard acid called Acidimetry and those are formed by hydrolysis of the salt of weak base with a standard base called Alkalimetry.


  • This reaction depends upon the combination of ions to form a precipitate.

for example: - -- - -- - Silver ion of solution in chloride.




  • Indicators are metal ions.


  • Some principle oxidizing agents are listed below : - - - -

KMnO4, Potassium dichromate, iodine, Potassium iodide, cerium (iv) sulphate.




  • Some principle reducing agents are listed below : - - - -

Vanadiun (II) chloride/sulphate, Titanium (II) chloride/sulphate, chromium (II) chloride/sulphate.




  • IUPAC definition of Mole : - - - - -

Amount of substance which contains as many elementary units as there are atoms in 0.012 Kg of C-12. The elementary units must be specified and may be an atom, molecule, ion, radical, an electon or other particle or specified group of such particles.




  • Molarity : - - - - Ratio of the moles of solute to the volume of solution in litres. It is denoted by capital M.

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